BizTalk end of life: why Axway is the best replacement

Microsoft has announced that by early 2028, it will end-of-life its legacy integration platform BizTalk and move the focus for integration solutions completely to Azure. This poses a very real challenge for organizations that either cannot — due to regulatory constraints — or choose not to operate within a US-regulated cloud environment.

It’s also a good time to rethink whether your legacy solution will still fulfill your organization’s integration needs ten years from now.

As companies evaluate alternatives to BizTalk, the need for a flexible, secure, and future-ready integration platform is clear. Axway offers a powerful replacement that not only supports existing integration patterns but also enables modernization and innovation across hybrid environments.

Why Axway is a future-ready alternative to BizTalk

Axway offers an alternative to BizTalk that checks all the boxes. Unlike Microsoft’s Azure-ecosystem focus, Axway supports true hybrid deployment, giving you control over where and how your integration platform runs:

• On-premises, for full control and data sovereignty
• Any local or global private or public cloud
• SaaS via Axway Cloud (which runs on Azure or AWS, with regional deployment options)

This flexibility ensures that organizations bound by data residency, sovereignty, or compliance requirements can continue integrating systems and partners without being locked into a single cloud infrastructure.

Beyond full hybrid deployment options, Axway also delivers:

1. Full support for all internal integration use cases.
2. Full support for all B2B use cases, including support for EDI.
3. A complete set of features to support company AI initiatives, including AI-led mapping automation, AI gateway capabilities, MCP support, and AI governance.

A unified platform for hybrid integration

With the combined strengths of Axway B2B Integration (B2B/EDI) and Amplify Fusion (API/EiPaaS), Axway offers a flexible and future-ready approach to integration — one that supports both legacy and modern systems, enables hybrid deployments, and helps organizations move toward unified, composable architectures.

Whether you’re looking to modernize at your own pace, extend the value of existing systems, or streamline integration across your ecosystem, Axway provides the tools, expertise, and platform to support that journey.

Let’s highlight how these two key Axway components work together while each remains best in class.

Axway B2B Integration: modernize EDI and meet global mandates

Axway B2B Integration allows organizations to simplify B2B integration through API and AI automation, unifying traditional EDI and modern API partner flows, and connecting with enterprise systems like SAP, Oracle, and Infor, so your transactions keep flowing no matter the volume or pattern.

It provides real-time visibility, streamlined partner onboarding, and high performance across legacy and modern protocols — including AS2, AS4, and industry-specific extensions like ENTSOG or OFTP (Odette FTP) connectivity.

See also: How DB Schenker keeps global logistics running smoothly with Axway B2Bi

Its flexible deployment options support on-premises, cloud, containers, or hybrid environments, allowing you to align integration with your infrastructure and compliance strategy.

Axway B2B goes beyond traditional EDI by offering APIs for configuration and transaction operations, empowering integration with modern ecosystems. It includes global e-invoicing compliance — covering mandates such as Peppol and CTC, and country-specific requirements in Germany, Spain, France, Poland, and Romania.

See also: All About EN-16931 for e-Invoicing Compliance in and Outside Europe

The solution also incorporates Axway Business Network, a modern API-capable VAN with competitive pricing and strong self-service and reporting capabilities, and tools for supplier enablement. It supports industry mandates including CSOS and Track-and-Trace, making it a comprehensive B2B integration hub built for scale, security, and global reach.

Amplify Fusion: orchestrate intelligent data flows across your ecosystem

Amplify Fusion helps enterprises accelerate digital transformation by breaking down integration silos and orchestrating intelligent, secure data flows across their entire ecosystem.

Built as a modern, cloud-native integration control plane, Fusion enables seamless orchestration across APIs, applications, data, files and events – with centralized governance and hybrid deployment flexibility. Its visual, low-code interface empowers both developers and business users to design integration flows without writing code.

Fusion includes a robust catalog of out-of-the box connectors and supports the creation of custom ones — enabling fast and flexible integration with cloud services, SaaS platforms, and legacy systems.

It supports real-time and event driven architectures, with hybrid deployment options (cloud, on-prem, containerized) and built-in governance, monitoring and error handling.

Whether you’re integrating Salesforce with SAP, automating critical file transfers, or exposing APIs securely across regions, Fusion delivers the agility and control needed to scale innovation without complexity.

While Fusion includes all core capabilities expected from an Integration Platform as a Service (iPaaS), it has been designed as something broader: a multi-pattern integration solution that’s purpose-built for today’s hybrid, data-rich, and AI-enabled enterprise environments.

Rather than limiting integration to SaaS applications and APIs alone, Fusion addresses a full spectrum of integration patterns, allowing organizations to modernize legacy systems, embrace event-driven architectures and securely enable new AI use-cases – all within a unified solution.

Together, Axway B2B Integration and Amplify Fusion support a wide range of integration scenarios. Let’s explore how they work in practice through three real-world use cases.

Use case #1: Streamlining disparate partner and backend integrations

An enterprise manages a vast and diverse partner network, including traditional EDI-based suppliers, API-enabled digital platforms, and smaller partners who prefer cloud-based or browser-based interaction. Internal systems span from legacy ERPs to modern SaaS applications and microservices.

Axway B2B Integration and Amplify Fusion work together to support this wide range of integration requirements:

• Traditional partners can exchange EDIFACT or X12 via AS2/SFTP.
• Digital-first partners use REST APIs
• Smaller or occasional partners interact via browser-based EDI portals or lightweight automated workflows.
• Besides point-to-point EDI, companies can also connect to VAN-driven suppliers thanks to our modern API-driven approach to VANs.
• Connect to APIs, cloud applications, databases, and iPaaS patterns internally, while managing structured EDI flows into legacy backend systems.

This hybrid model gives enterprises the flexibility to onboard any partner using their preferred method, integrate with any internal system, and maintain full visibility, scalability, and compliance across all transactions.

Use case #2: Compliant and cost-effective B2B/EDI data exchange with trading partners

An organization exchanges EDI files (e.g., purchase orders, invoices, shipment notices) using traditional protocols like AS2 or SFTP with external partners and routes them directly to and from internal ERP systems using the same standards.

Axway B2B Integration plays a central role here, managing the full transaction lifecycle — including message transformation, routing, validation, SLA monitoring, and secure transport. It ensures compliance with industry standards (e.g., EDIFACT, X12), supports high-volume throughput, and simplifies partner onboarding.

This model is ideal for mature, stable trading relationships in sectors such as manufacturing, logistics, or retail, where classic EDI remains the standard.

Importantly, Axway B2B also includes powerful API capabilities, supporting hybrid interactions such as EDI-to-JSON transformations, and offering APIs for the automation of configuration and operations, that enable more agile, API-enabled EDI use-cases.

Use case #3: API-first integration for cloud-native ecosystems

A company integrates with cloud-native trading partners, such as online marketplaces, fintech platforms, or modern logistics providers using REST APIs, and exchanges data with internal systems through APIs or connectors.

Amplify Fusion takes the lead in this scenario, orchestrating real-time, API-driven integrations between external systems and internal business apps like Salesforce, ServiceNow, SAP, or custom-built platforms.

For example, a retail brand might use Fusion to automate inventory updates between an e-commerce partner and their ERP system, leveraging prebuilt connectors and event-driven workflows for end-to-end automation — all with minimal coding effort.

Axway offers a smarter path to unified integration

Axway’s fully hybrid integration solutions are a powerful replacement for Microsoft Biztalk — especially for organizations that require flexibility beyond a single cloud.

Whether you’re modernizing legacy systems, enabling real-time API flows, or preparing for AI-driven automation, Axway provides the tools and expertise to support your journey.